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To research the impact of IKK2 inhibitor VIII (HY-13060, Medchem Specific, Monmouth Junction, NJ) on OA advancement, MLI surgical procedures have been executed in twelve-7 days-old C57BL/six WT mice. The mice ended up injected with IKK2 inhibitor VIII (2?mg/kg, IP) every alternate working day for 5 weeks. OARSI scoring was executed by blinded revie